EVIDENCE · MICROSCOPIA NETWORK

microscopIA-governed projects and collaborations

Explore outputs from research governed by microscopIA or conducted in collaboration. Each record distinguishes scientific responsibility, affiliations, editorial status and source.

How to read this portfolio

“Governed” identifies projects under microscopIA scientific responsibility and approval processes. “Collaboration” identifies work conducted jointly. An author’s affiliation alone does not make an output a governed project.

A selection of our work. Some projects in progress or peer review are not disclosed under confidentiality agreements with their investigators.

How to read the numbers

Clinical outcomes

A percentage describes a proportion within the stated group. A risk ratio compares two risks: 1 means equal risks; 2 means twice the risk in the stated comparison, not twice the number of patients. Association alone does not establish causation.

Number needed to treat

The estimated number of people treated for one additional benefit over a specified period and comparator. It depends on baseline risk and uncertainty.

Read the BMJ methods article ↗

Health economics

A quality-adjusted life-year (QALY) combines length and quality of life. Net monetary benefit (NMB) values health gains at the study’s stated threshold, then subtracts costs. A cost-effectiveness probability summarizes model uncertainty; it is not the probability that a patient improves.

Read about cost-effectiveness uncertainty ↗

Comparisons and precision

Read the group order, units, study design and follow-up alongside each estimate. Counts remain whole numbers; monetary and percentage estimates use two decimal places where supported. See the source for confidence intervals and limitations.

microscopIA GovernedmicroscopIA CollaborationIndependent Network Record11 projects
microscopIA CollaborationCase reportPreprint availablePeer reviewVerified 2026-08-19

Pediatric trauma and reconstructive surgery

Staged orthoplastic reconstruction of an 8-cm open Achilles tendon defect after crush trauma in a 7-year-old child: a case report

Preprint available · Peer review at Journal of Medical Case Reports

Study aim

This case report describes the staged orthoplastic reconstruction of an 8-cm open Achilles tendon defect following crush trauma in a 7-year-old child, focusing on the reconstructive strategy used to restore tendon continuity and soft-tissue coverage after severe injury.

Study design
Clinical case report
Geography
Colombia
Preprint record
Research Square · 2026-07-17 · v1 · CC BY 4.0
Verification source
Research Square preprint and current Springer submission record
Pediatric traumaAchilles tendonOrthoplastic reconstructionPediatric orthopedicsReconstructive surgeryReverse sural flapSemitendinosus autograftCase report+1 more
Capabilities involvedResearch & EpidemiologyBiomedical Engineering & DevicesScientific Publication
Authors and manuscript affiliations

microscopIA scientists

Camilo Perdomo-LunaNetwork profile →Department of Radiology and Imaging Science, Emory University, Atlanta, USA
Jorge RacedoNetwork profile →Global Studies Institute, University of Geneva, Geneva, Switzerland

External collaborators

Esteban Salgar-SaiehClínica San José, Colombia
Santiago Otero-ParraPontificia Universidad Javeriana, Colombia
Carlos A. Salgar-VillamizarClínica San José, Colombia
Ángel Barreto CastillaClínica San José, Colombia
microscopIA GovernedOriginal research · Health economic evaluationPreprint availablePeer reviewVerified 2026-10-03

Retinopathy of prematurity and health economics

Economic evaluation of topical ketorolac and nepafenac prophylaxis for early-stage retinopathy of prematurity: a multicenter real-world study in Colombia

Preprint available · Peer review at Cost Effectiveness and Resource Allocation

Study aim

This study evaluates the cost-effectiveness of topical ketorolac and nepafenac prophylaxis for early-stage retinopathy of prematurity using multicenter real-world clinical and economic data from Colombia.

Study design
Multicenter real-world economic evaluation
Geography
Colombia · 14 centers
Initiative
Global Retinopathy of Prematurity Observatory
Preprint record
Research Square · v1
Verification source
Author-deposited Crossref abstract for 10.21203/rs.3.rs-10100738/v1; existing submission status or current leadership confirmation
Retinopathy of prematurityHealth economicsCost-effectivenessReal-world evidenceKetorolacNepafenacNSAIDsProphylaxis+4 more
Selected study metrics
Cohort192 infants

48 ketorolac, 98 nepafenac and 46 historical surveillance comparators.

Probability cost-effective: ketorolac71.90%
Probability cost-effective: nepafenac68.16%
Capabilities involvedHealth EconomicsResearch & EpidemiologyData Science & Statistics
Authors and manuscript affiliations

microscopIA scientists

Giliana García-AcevedoNetwork profile →Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
Jorge Eduardo Silva MorenoNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, Colombia
Karol Valeria Guerrero BeltránNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaSchool of Medicine, Universidad de Los Andes, Bogotá, Colombia
Wilman Sánchez-HernándezNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaDepartment of Engineering and Artificial Intelligence, microscopIA, Bogotá, Colombia
Camilo Perdomo-LunaNetwork profile →Department of Radiology and Imaging Science, Emory University, Atlanta, USASchool of Health Systems Engineering and Global Health, microscopIA, Bogotá, Colombia
Jorge RacedoNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaGlobal Studies Institute, University of Geneva, Geneva, Switzerland

External collaborators

Bryan N. Forero VásquezDepartment of Research and Innovation, microscopIA, Bogotá, ColombiaDepartment of Internal Medicine, Fundación Universitaria San Martín, Bogotá, Colombia
microscopIA GovernedOriginal research · Real-world clinical evidencePreprint availableRevisionVerified 2026-10-03

Retinopathy of prematurity

Topical ketorolac and nepafenac prophylaxis in early retinopathy of prematurity: real-world clinical evidence from a multicenter care network in Colombia

Preprint available · Revision at BMC Pediatrics

Study aim

This study evaluates real-world clinical outcomes associated with topical ketorolac and nepafenac prophylaxis for early-stage retinopathy of prematurity across a multicenter care network in Colombia.

Study design
Multicenter real-world cohort
Geography
Colombia · multicenter care network
Initiative
Global Retinopathy of Prematurity Observatory
Preprint record
Research Square · v1
Verification source
Author-deposited Crossref abstract for 10.21203/rs.3.rs-10099758/v1; existing submission status or current leadership confirmation
Retinopathy of prematurityReal-world evidenceKetorolacNepafenacTopical NSAIDsProphylaxisClinical outcomesPediatric ophthalmology+3 more
Selected study metrics
Cohort192 infants

48 ketorolac, 98 nepafenac and 46 historical surveillance comparators.

Treatment-requiring ROP20.83% ketorolac · 22.45% nepafenac · 45.65% historical comparator
Estimated number needed to treat4 for each agent

Observational estimate, not a randomized efficacy result.

Capabilities involvedResearch & EpidemiologyData Science & StatisticsScientific Publication
Selected authors and manuscript affiliations

This is a selected list. The linked publication contains the complete, authoritative author and affiliation list.

microscopIA scientists

External collaborators

Julio C. Racero MendozaUniversidad del Sinú
Laura C. Montoya BurgosUniversidad del Sinú
Stephany Abud CogolloUniversidad Simón Bolívar
microscopIA GovernedOriginal research · National geospatial health-systems analysisPreprint availablePeer reviewVerified 2026-08-19

Transplantation and health-system access

Graft-specific travel-time accessibility and underserved zones in Colombia’s transplant system

Preprint available · Peer review at BMC Public Health

Study aim

This study evaluates graft-specific geographic accessibility to transplant-capable services across Colombia and identifies populations living beyond clinically relevant travel-time thresholds to support transplant-network planning and identify underserved areas.

Study design
National cross-sectional geospatial analysis
Geography
Colombia · national
Preprint record
Research Square · 2026-07-23 · v1 · CC BY 4.0
Verification source
Research Square preprint and current Springer submission record
TransplantationGeospatial analysisGeographic accessibilityTravel-time accessibilityHealth systemsHealth equityHealth system planningService accessibility+3 more
Capabilities involvedGeospatial & Access AnalysisPolicy & Decision IntelligenceResearch & Epidemiology
Authors and manuscript affiliations

microscopIA scientists

Juan José Ramírez MeloNetwork profile →microscopIA, Bogotá, ColombiaUniversidad Tecnológica Nacional, Buenos Aires Regional Faculty, Argentina
David F. Estupiñán PepinosaNetwork profile →microscopIA, Bogotá, ColombiaSchool of Medicine, Universidad de Los Andes, Bogotá, Colombia
Ariadna Haydar ChamsNetwork profile →microscopIA, Bogotá, ColombiaSchool of Medicine, Universidad del Norte, Barranquilla, Colombia
Camilo Perdomo-LunaNetwork profile →microscopIA, Bogotá, ColombiaEmory University, Atlanta, USA
Agamenón Quintero VillarrealNetwork profile →microscopIA, Bogotá, ColombiaClínica IMAT Oncomédica Auna, Montería, ColombiaUniversidad del Sinú, Colombia
Jorge RacedoNetwork profile →microscopIA, Bogotá, ColombiaUniversity of Geneva, Geneva, Switzerland
microscopIA GovernedOriginal research · Health economic evaluationPreprint availablePeer reviewVerified 2026-10-03

Retinopathy of prematurity and health economics

Cost-effectiveness of bevacizumab versus ranibizumab for treatment-requiring retinopathy of prematurity: a multicenter real-world cohort study

Preprint available · Peer review at Cost Effectiveness and Resource Allocation

Study aim

This study compares the cost-effectiveness of bevacizumab and ranibizumab for treatment-requiring retinopathy of prematurity using multicenter real-world clinical and economic data.

Study design
Multicenter real-world cohort and economic evaluation
Geography
Colombia · 14 centers
Initiative
Global Retinopathy of Prematurity Observatory
Preprint record
Research Square · v1
Verification source
Author-deposited Crossref abstract for 10.21203/rs.3.rs-10181962/v1; existing submission status or current leadership confirmation
Retinopathy of prematurityHealth economicsCost-effectivenessAnti-VEGFBevacizumabRanibizumabReal-world evidenceMulticenter cohort+3 more
Selected study metrics
Retreatment6.38% vs 48.65%

Observed retreatment after bevacizumab and ranibizumab, respectively.

Net monetary benefitUSD 1,022.93

Incremental net value favoring bevacizumab at the study threshold.

Probability cost-effective86.55%

Share of probabilistic simulations favoring bevacizumab.

Capabilities involvedHealth EconomicsResearch & EpidemiologyData Science & Statistics
Selected authors and manuscript affiliations

This is a selected list. The linked publication contains the complete, authoritative author and affiliation list.

microscopIA scientists

External collaborators

Andrea Carolina Rincon AlvaradomicroscopIA
microscopIA GovernedOriginal research · National geospatial health-systems analysisPreprint availablePeer reviewVerified 2026-09-28

Critical care access and health-system planning

Prolonged travel time to intensive care in Colombia: a national analysis to inform critical care policy and network design

Preprint available · Peer review at Scientific Reports

Principal investigators: Dr. Joseph L. Nates · Dr. Agamenón Quintero Villarreal · Jorge Racedo

Study aim

This study evaluates population-level travel-time access to intensive-care services across Colombia and identifies areas with prolonged geographic access to inform critical-care policy, service planning, and network design.

Study design
National geospatial accessibility analysis
Geography
Colombia · national
Initiative
Global Critical Care Observatory
Preprint record
Research Square · 2026-07-17 · v1 · CC BY 4.0
Verification source
Research Square preprint; principal investigators and peer-review status confirmed by programme leadership on 28 September 2026
Critical careIntensive careICUGeospatial analysisGeographic accessibilityTravel-time accessibilityHealth systemsHealth policy+5 more
Selected study metrics
Adult intensive-care units419 units
Pediatric intensive-care units132 units
Adult intensive-care unit (ICU) access within 2 hours76.50% of the population
Capabilities involvedGeospatial & Access AnalysisPolicy & Decision IntelligenceResearch & Epidemiology
Selected authors and manuscript affiliations

This is a selected list. The linked publication contains the complete, authoritative author and affiliation list.

microscopIA scientists

Agamenón Quintero VillarrealNetwork profile →Clínica IMAT Oncomédica Auna, Montería, Colombia
Joseph L. NatesNetwork profile →The University of Texas MD Anderson Cancer Center, Houston, USA

External collaborators

Sarah C. PérezmicroscopIA, Bogotá, Colombia
Andrés José Romero BurgosFundación Universitaria de Ciencias de la Salud and Hospital de San José, Bogotá, Colombia
microscopIA GovernedOriginal research · National geospatial health-systems analysisPreprint availablePeer reviewVerified 2026-10-03

Retinopathy of prematurity workforce and access

Retinopathy of prematurity care in Colombia: workforce distribution, geographic accessibility, and emerging practice patterns

Preprint available · Peer review at Scientific Reports

Study aim

This study characterizes the distribution of the retinopathy of prematurity workforce in Colombia, evaluates geographic accessibility to care, and examines emerging practice patterns to identify gaps relevant to national service planning.

Study design
National workforce and travel-time accessibility analysis
Geography
Colombia · 1,103 municipalities
Initiative
Global Retinopathy of Prematurity Observatory
Preprint record
Research Square · v1
Verification source
Author-deposited Crossref abstract for 10.21203/rs.3.rs-10819022/v1; existing submission status or current leadership confirmation
Retinopathy of prematurityPediatric ophthalmologyWorkforceGeographic accessibilityTravel-time accessibilityGeospatial analysisHealth systemsHealth equity+2 more
Selected study metrics
Verified providers54 clinicians
Municipalities with providers51 of 1,103 municipalities
More than 120 minutes from retina care46.30% of the population
Capabilities involvedGeospatial & Access AnalysisPolicy & Decision IntelligenceResearch & Epidemiology
Selected authors and manuscript affiliations

This is a selected list. The linked publication contains the complete, authoritative author and affiliation list.

microscopIA scientists

External collaborators

Laura Sofía Cañón BuitragoUniversidad de La Sabana
Sarah C. PérezUniversidad de Los Andes
Stephany Abud CogolloUniversidad Simón Bolívar
microscopIA CollaborationSystematic review · Risk-of-bias assessmentSubmittedSubmittedVerified 2026-10-03

Obstetric critical care

Prediction Models for Mortality in Critically Ill Obstetric Patients: A Systematic Review and Risk-of-Bias Assessment

Submitted · Submitted at Critical Care Medicine

Principal investigators: Dr. Joseph L. Nates · Jorge Racedo

Study aim

A systematic review examining mortality prediction models in critically ill obstetric patients and assessing risk of bias in the underlying studies.

Study design
Systematic review
Geography
Evidence synthesis
Initiative
Global Critical Care Observatory
Verification source
Manuscript title supplied in author correspondence; submission status and principal investigators confirmed by programme leadership
Critical careObstetric critical careMortalityPrediction modelsSystematic reviewRisk of bias
Capabilities involvedResearch & EpidemiologyData Science & StatisticsScientific Publication
Authors and manuscript affiliations

microscopIA scientists

Wilman Sánchez-HernándezNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaDepartment of Biomedical Engineering, Universidad de Los Andes, Bogotá, Colombia
Brigithe Noel-AvendañoNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaFaculty of Medicine, Universidad del Magdalena, Santa Marta, Colombia
Joseph L. NatesNetwork profile →Division of Anesthesiology, Critical Care, and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Jorge RacedoNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, Colombia

External collaborators

Nirmala ManjappacharDepartment of Pulmonary Medicine, Rosalind Franklin University of Medicine and Science–Chicago Medical School, Chicago, Illinois, USA
Mary Catherine TolcherDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA
microscopIA CollaborationOriginal research · Clinical cohortSubmittedSubmittedVerified 2026-09-28

Obstetric critical care

Rural–urban differences in critical care resource use and in-hospital outcomes among obstetric intensive care admissions in Colombia: a retrospective cohort study, 2014–2018

Submitted · Submitted at BMC Pregnancy and Childbirth

Principal investigators: Dr. Francisco Camargo-Assis

Study aim

This study evaluates rural–urban differences in obstetric intensive-care admission, organ support, resource use, and maternal–fetal outcomes within a Colombian hospital cohort from 2014 through 2018.

Study design
Retrospective cohort
Geography
Colombia
Initiative
Global Critical Care Observatory
Verification source
microscopIA project register; principal investigator confirmed by programme leadership on 28 September 2026
Critical careObstetric critical careRural healthHealth equityRetrospective cohortColombia
Selected study metrics
Final cohort257 patients
Invasive mechanical ventilationCrude RR 2.99 (95% CI 1.05–8.50)
Packed red-cell transfusionCrude RR 1.89 (95% CI 1.09–3.27)
Capabilities involvedResearch & EpidemiologyData Science & StatisticsScientific Publication
Authors and manuscript affiliations

microscopIA scientists

Francisco Camargo-AssisNetwork profile →Global Critical Care Observatory, microscopIA, Bogotá, ColombiaDepartment of Critical Care Medicine, Clínica Zayma, Montería, ColombiaSchool of Medicine, Universidad del Sinú, Montería, Colombia
Jorge Eduardo Silva MorenoNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaSchool of Medicine, Universidad de Nariño, Pasto, Colombia
Ana María Sánchez RuedaNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaSchool of Medicine, Fundación Universitaria de Ciencias de la Salud, Hospital de San José, Bogotá, Colombia
Carlos Santiago Rivadeneira-ChamorroNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaSchool of Medicine, Fundación Universitaria de Ciencias de la Salud, Hospital de San José, Bogotá, Colombia
Juan José Ramírez MeloNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaBuenos Aires Regional Faculty, Universidad Tecnológica Nacional, Buenos Aires, Argentina
Brigithe Lorena Noel AvendañoNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaSchool of Medicine, Universidad del Magdalena, Santa Marta, Colombia
María Paulina Racedo GalvánNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaDepartment of Internal Medicine, Hospital Privado Nuestra Señora de la Merced, Buenos Aires, Argentina
Giliana García-AcevedoNetwork profile →Department of Research and Innovation, microscopIA, Bogotá, ColombiaDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Camilo Perdomo-LunaNetwork profile →Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USADepartment of Engineering and Artificial Intelligence, microscopIA, Bogotá, Colombia
Jorge RacedoNetwork profile →Global Critical Care Observatory, microscopIA, Bogotá, ColombiaDepartment of Engineering and Artificial Intelligence, microscopIA, Bogotá, ColombiaGlobal Studies Institute, University of Geneva, Geneva, Switzerland
microscopIA GovernedMethods research · Health economic evaluationManuscript preparationVerified 2026-08-18

Health economics and decision science

Empirical instability of the incremental cost-effectiveness ratio in probabilistic economic evaluation

Manuscript preparation

Study aim

This methodological study evaluates the empirical stability of the incremental cost-effectiveness ratio relative to net monetary benefit under probabilistic uncertainty, examining which metric communicates decision uncertainty more reliably.

Study design
Probabilistic simulation study
Geography
Methodological
Initiative
Global Health Economics and Decision Science Observatory
Verification source
microscopIA project register
Health economicsCost-effectivenessDecision scienceProbabilistic sensitivity analysisNet monetary benefit
Selected study metrics
Deterministic incremental cost-effectiveness ratio (ICER)−USD 14,927.00 per quality-adjusted life-year (QALY)
Incremental cost-effectiveness ratio (ICER) coefficient of variation25.71%
Net monetary benefit (NMB) coefficient of variation1.52%
Capabilities involvedHealth EconomicsData Science & Statistics
microscopIA GovernedInnovation · Development programOngoing researchVerified 2026-10-03

Artificial intelligence and biomedical engineering

AI-assisted retinopathy-of-prematurity screening pathway

Ongoing research

Study aim

An investigational AI pathway supports neonatologists, neonatal nurses, general practitioners and other primary-care staff in flagging suspected ROP and referring infants promptly to pediatric ophthalmologists, retina/vitreous specialists or other clinicians trained in ROP. The AI does not diagnose ROP; specialist assessment and routine surveillance remain essential.

Study design
Protocol and system development
Geography
Colombia
Initiative
Global Retinopathy of Prematurity Observatory
Verification source
Intended-use scope confirmed by microscopIA leadership on 3 October 2026
Retinopathy of prematurityArtificial intelligenceComputer visionMedical deviceClinical validationColombia
Capabilities involvedArtificial IntelligenceBiomedical Engineering & DevicesReal-World Implementation

PUBLISHED BOOK CHAPTERS · CRITICAL CARE

Five chapters in Oncologic Critical Care

A published Springer contribution on electrolyte disorders in critically ill patients with cancer. Each chapter is linked to its publisher record and shown here as scholarly output—not as a standalone clinical recommendation.

Published microscopIA affiliation: Department of Health Systems Engineering and Global Health, microscopIA, Bogotá, Colombia.

  1. 01

    Electrolytic Abnormalities Related to Calcium in Critically Ill Cancer Patients

    Oncologic Critical Care · Springer Nature · DOI: 10.1007/978-3-319-74698-2_84-2

    Published · 2026View publisher record ↗
  2. 02

    Electrolytic Abnormalities Related to Phosphate in Critically Ill Cancer Patients

    Oncologic Critical Care · Springer Nature · DOI: 10.1007/978-3-319-74698-2_85-2

    Published · 2026View publisher record ↗
  3. 03

    Electrolytic Abnormalities Related to Sodium in Critically Ill Cancer Patients

    Oncologic Critical Care · Springer Nature · DOI: 10.1007/978-3-319-74698-2_86-2

    Published · 2026View publisher record ↗
  4. 04

    Electrolytic Abnormalities Related to Potassium in Critically Ill Cancer Patients

    Oncologic Critical Care · Springer Nature · DOI: 10.1007/978-3-319-74698-2_87-2

    Published · 2026View publisher record ↗
  5. 05

    Electrolytic Abnormalities Related to Magnesium in Critically Ill Cancer Patients

    Oncologic Critical Care · Springer Nature · DOI: 10.1007/978-3-319-74698-2_88-2

    Published · 2026View publisher record ↗

View independent member scholarship →